Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies
Identifieur interne : 001974 ( Main/Exploration ); précédent : 001973; suivant : 001975Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies
Auteurs : H. Kasai [Japon] ; E. Morita [Japon] ; K. Hatakeyama [Japon] ; K. Sugiyama [Japon]Source :
- Archives of Virology [ 0304-8608 ] ; 1998-10-01.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux (immunologie), Coronavirus (), Coronavirus (physiologie), Hémagglutinines virales (analyse), Hémagglutinines virales (immunologie), Hémagglutinines virales (physiologie), Protéines de fusion virale, Protéines virales (analyse), Protéines virales (immunologie), Protéines virales (physiologie), Souris.
- MESH :
- analyse : Hémagglutinines virales, Protéines virales.
- immunologie : Anticorps monoclonaux, Hémagglutinines virales, Protéines virales.
- physiologie : Coronavirus, Hémagglutinines virales, Protéines virales.
- Animaux, Coronavirus, Protéines de fusion virale, Souris.
- Pascal (Inist)
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (immunology), Antigen, Antigenic determinant, Characterization, Coronavirus (chemistry), Coronavirus (physiology), Esterases, Hemagglutinin, Hemagglutinins, Viral (analysis), Hemagglutinins, Viral (immunology), Hemagglutinins, Viral (physiology), Mice, Monoclonal antibody, Murine hepatitis virus, Protein, Viral Fusion Proteins, Viral Proteins (analysis), Viral Proteins (immunology), Viral Proteins (physiology), Virus surface.
- MESH :
- chemical , analysis : Hemagglutinins, Viral, Viral Proteins.
- chemical , immunology : Antibodies, Monoclonal, Hemagglutinins, Viral, Viral Proteins.
- chemistry : Coronavirus.
- physiology : Coronavirus, Hemagglutinins, Viral, Viral Proteins.
- Animals, Mice, Viral Fusion Proteins.
Abstract
Summary: We analyzed the characteristics of seven monoclonal antibodies (mAbs) raised against purified HE (hemagglutinin-esterase) glycoprotein of the murine coronavirus DVIM (diarrhea virus of infant mice). Immunocrossreaction of these mAbs with JHM and/or MHV-S suggest that antigenic epitopes of HE of DVIM are similar to those of JHM and/or MHV-S. Four mAbs (1b4, 3Aff28, 4c19, 10b7), designated as group A mAbs, strongly inhibited both HA and AE activities. On the other hand, three mAbs (5Aff3, 6Aff6, 13Aff4), referred to as group B, had a comparatively weak HA inhibition activity. These results indicate that the antigenic epitopes of this glycoprotein can be classified into at least two groups and that the functional sites of HA and AE activities are similar but not identical. Neutralizing activity was shown in group A mAbs exclusively, suggesting that the ratio of HA and/or AE activities may play important roles in the cell fusion activity of DVIM-infected cells.
Url:
- https://api.istex.fr/ark:/67375/VQC-40X8N0R4-Z/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086726
DOI: 10.1007/s007050050431
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000124
- to stream Istex, to step Curation: 000092
- to stream Istex, to step Checkpoint: 000397
- to stream Pmc, to step Corpus: 000188
- to stream Pmc, to step Curation: 000188
- to stream Pmc, to step Checkpoint: 000A37
- to stream PubMed, to step Corpus: 000D81
- to stream PubMed, to step Curation: 000D81
- to stream PubMed, to step Checkpoint: 000D61
- to stream Ncbi, to step Merge: 001695
- to stream Ncbi, to step Curation: 001695
- to stream Ncbi, to step Checkpoint: 001695
- to stream Main, to step Merge: 001987
- to stream PascalFrancis, to step Corpus: 000060
- to stream PascalFrancis, to step Curation: 000070
- to stream PascalFrancis, to step Checkpoint: 000060
- to stream Main, to step Merge: 001991
- to stream Main, to step Curation: 001974
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies</title><author><name sortKey="Kasai, H" sort="Kasai, H" uniqKey="Kasai H" first="H." last="Kasai">H. Kasai</name></author><author><name sortKey="Morita, E" sort="Morita, E" uniqKey="Morita E" first="E." last="Morita">E. Morita</name></author><author><name sortKey="Hatakeyama, K" sort="Hatakeyama, K" uniqKey="Hatakeyama K" first="K." last="Hatakeyama">K. Hatakeyama</name></author><author><name sortKey="Sugiyama, K" sort="Sugiyama, K" uniqKey="Sugiyama K" first="K." last="Sugiyama">K. Sugiyama</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:31F3EAF23581BD0CFE55F831FC7FF62348F62DF9</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1007/s007050050431</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-40X8N0R4-Z/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000124</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000124</idno><idno type="wicri:Area/Istex/Curation">000092</idno><idno type="wicri:Area/Istex/Checkpoint">000397</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000397</idno><idno type="wicri:doubleKey">0304-8608:1998:Kasai H:characterization:of:haemagglutinin</idno><idno type="wicri:source">PMC</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086726</idno><idno type="RBID">PMC:7086726</idno><idno type="wicri:Area/Pmc/Corpus">000188</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000188</idno><idno type="wicri:Area/Pmc/Curation">000188</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000188</idno><idno type="wicri:Area/Pmc/Checkpoint">000A37</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A37</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:9856082</idno><idno type="wicri:Area/PubMed/Corpus">000D81</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D81</idno><idno type="wicri:Area/PubMed/Curation">000D81</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D81</idno><idno type="wicri:Area/PubMed/Checkpoint">000D61</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D61</idno><idno type="wicri:Area/Ncbi/Merge">001695</idno><idno type="wicri:Area/Ncbi/Curation">001695</idno><idno type="wicri:Area/Ncbi/Checkpoint">001695</idno><idno type="wicri:doubleKey">0304-8608:1998:Kasai H:characterization:of:haemagglutinin</idno><idno type="wicri:Area/Main/Merge">001987</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:99-0084586</idno><idno type="wicri:Area/PascalFrancis/Corpus">000060</idno><idno type="wicri:Area/PascalFrancis/Curation">000070</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000060</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000060</idno><idno type="wicri:doubleKey">0304-8608:1998:Kasai H:characterization:of:haemagglutinin</idno><idno type="wicri:Area/Main/Merge">001991</idno><idno type="wicri:Area/Main/Curation">001974</idno><idno type="wicri:Area/Main/Exploration">001974</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies</title><author><name sortKey="Kasai, H" sort="Kasai, H" uniqKey="Kasai H" first="H." last="Kasai">H. Kasai</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biology, Faculty of Science, Hirosaki University, Hirosaki, Japan</wicri:regionArea><wicri:noRegion>Japan</wicri:noRegion></affiliation></author><author><name sortKey="Morita, E" sort="Morita, E" uniqKey="Morita E" first="E." last="Morita">E. Morita</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biology, Faculty of Science, Hirosaki University, Hirosaki, Japan</wicri:regionArea><wicri:noRegion>Japan</wicri:noRegion></affiliation></author><author><name sortKey="Hatakeyama, K" sort="Hatakeyama, K" uniqKey="Hatakeyama K" first="K." last="Hatakeyama">K. Hatakeyama</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biology, Faculty of Science, Hirosaki University, Hirosaki, Japan</wicri:regionArea><wicri:noRegion>Japan</wicri:noRegion></affiliation></author><author><name sortKey="Sugiyama, K" sort="Sugiyama, K" uniqKey="Sugiyama K" first="K." last="Sugiyama">K. Sugiyama</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Biology, Faculty of Science, Hirosaki University, Hirosaki, Japan</wicri:regionArea><wicri:noRegion>Japan</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Archives of Virology</title><title level="j" type="abbrev">Arch. Virol.</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1998-10-01">1998-10-01</date><biblScope unit="volume">143</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1941">1941</biblScope><biblScope unit="page" to="1948">1948</biblScope></imprint><idno type="ISSN">0304-8608</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-8608</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal (immunology)</term><term>Antigen</term><term>Antigenic determinant</term><term>Characterization</term><term>Coronavirus (chemistry)</term><term>Coronavirus (physiology)</term><term>Esterases</term><term>Hemagglutinin</term><term>Hemagglutinins, Viral (analysis)</term><term>Hemagglutinins, Viral (immunology)</term><term>Hemagglutinins, Viral (physiology)</term><term>Mice</term><term>Monoclonal antibody</term><term>Murine hepatitis virus</term><term>Protein</term><term>Viral Fusion Proteins</term><term>Viral Proteins (analysis)</term><term>Viral Proteins (immunology)</term><term>Viral Proteins (physiology)</term><term>Virus surface</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps monoclonaux (immunologie)</term><term>Coronavirus ()</term><term>Coronavirus (physiologie)</term><term>Hémagglutinines virales (analyse)</term><term>Hémagglutinines virales (immunologie)</term><term>Hémagglutinines virales (physiologie)</term><term>Protéines de fusion virale</term><term>Protéines virales (analyse)</term><term>Protéines virales (immunologie)</term><term>Protéines virales (physiologie)</term><term>Souris</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Hemagglutinins, Viral</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Hemagglutinins, Viral</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Hémagglutinines virales</term><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps monoclonaux</term><term>Hémagglutinines virales</term><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term><term>Hémagglutinines virales</term><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term><term>Hemagglutinins, Viral</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Mice</term><term>Viral Fusion Proteins</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Coronavirus</term><term>Protéines de fusion virale</term><term>Souris</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Anticorps monoclonal</term><term>Antigène</term><term>Caractérisation</term><term>Déterminant antigénique</term><term>Esterases</term><term>Hémagglutinine</term><term>Protéine</term><term>Surface virus</term><term>Virus hépatite murine</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: We analyzed the characteristics of seven monoclonal antibodies (mAbs) raised against purified HE (hemagglutinin-esterase) glycoprotein of the murine coronavirus DVIM (diarrhea virus of infant mice). Immunocrossreaction of these mAbs with JHM and/or MHV-S suggest that antigenic epitopes of HE of DVIM are similar to those of JHM and/or MHV-S. Four mAbs (1b4, 3Aff28, 4c19, 10b7), designated as group A mAbs, strongly inhibited both HA and AE activities. On the other hand, three mAbs (5Aff3, 6Aff6, 13Aff4), referred to as group B, had a comparatively weak HA inhibition activity. These results indicate that the antigenic epitopes of this glycoprotein can be classified into at least two groups and that the functional sites of HA and AE activities are similar but not identical. Neutralizing activity was shown in group A mAbs exclusively, suggesting that the ratio of HA and/or AE activities may play important roles in the cell fusion activity of DVIM-infected cells.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Kasai, H" sort="Kasai, H" uniqKey="Kasai H" first="H." last="Kasai">H. Kasai</name></noRegion><name sortKey="Hatakeyama, K" sort="Hatakeyama, K" uniqKey="Hatakeyama K" first="K." last="Hatakeyama">K. Hatakeyama</name><name sortKey="Morita, E" sort="Morita, E" uniqKey="Morita E" first="E." last="Morita">E. Morita</name><name sortKey="Sugiyama, K" sort="Sugiyama, K" uniqKey="Sugiyama K" first="K." last="Sugiyama">K. Sugiyama</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001974 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001974 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:31F3EAF23581BD0CFE55F831FC7FF62348F62DF9
|texte= Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies
}}
| This area was generated with Dilib version V0.6.33. |  |